The five peptide families most relevant to endurance athletes span a wide evidence spectrum
Active peptides on broken skin sting, irritate, and can worsen the local inflammation
NAD+ PRECURSORS (NMN, NR, NA) Both approaches enhance NAD+-dependent metabolism but through distinct mechanisms: NAD+ precursors (NMN, NR): Provide substrate for NAD+ synthesis, increasing NAD+ production 5-Amino-1MQ: Inhibits NAD+ depletion by suppressing NNMT, preserving existing NAD+ These approaches are mechanistically complementary
Acknowledgements This research was supported by the Stanley Medical Research Institute (SMRI) and the donations of the Stanley brain collection courtesy of Drs Michael B Knable, E Fuller Torrey, Maree J Webster, Serge Weis and Robert H Yolken
The most important factor is consistency: your body adapts to predictable dosing patterns, so switching between morning and evening randomly is more disruptive than picking one and maintaining it
