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Campo pioneered research in this field, discovering in the early 1930s that a class of peptides called 'incretins' could promote - cells' insulin release, promoting blood-sugar metabolism, appetite regulation, and subsequent weight loss

This state of immune-tolerance derives from multiple mechanisms such as the mucus barrier minimizing the contact between intestinal microbiota and IECs, and the secretion of antimicrobial peptides like lysozyme, defensins, and immunoglobulin A [10]

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