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The mechanism is multifactorial: fibroblast activation, matrix-protein modulation, and inflammatory damping

Selenium-rich foods: organ meats, cottage cheese, brown rice, Brazil nuts, or a supplement

Deficiency in riboflavin transporter 1 is another quite rare metabolic disorder due to autosomal dominant pathogenic variants in the SLC52A1 gene (OMIM #615026)

A further study documented that the use of certolizumab pegol in female subjects with moderate to severe unremitting IC offered greater symptom relief than a placebo [30]