When starting both medications together, or adding one to an established regimen of the other, patients should: Take sertraline with food to minimise gastric irritation Follow the gradual dose titration schedule for Mounjaro as prescribed Stay well hydrated, especially if experiencing vomiting or diarrhoea Report persistent or severe gastrointestinal symptoms to their GP Risk of dehydration and kidney function : If significant vomiting or diarrhoea occurs, it's important to maintain adequate hydration
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Clinical trials showed that 9% of patients taking 510 mg doses and 10% of patients taking 15 mg doses experienced abdominal pain, compared to just 5% taking a placebo
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While both can cause abdominal discomfort, typical semaglutide-related symptoms include diffuse abdominal cramping, nausea, and changes in bowel habits that generally improve over time and are not localized to the right upper quadrant
