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Other concerning symptoms included neurologic (headache, visual changes, irritability, stiff neck [26%-86%]), oral mucous membrane involvement (29%-76%), and skin desquamation (18%-19%)

While the gastrointestinal effects (nausea, diarrhea, vomiting) are similar to other GLP-1 medications like Wegovy and Mounjaro, retatrutide has one unique finding: dysesthesia (abnormal touch sensations) in 20.9% of patients at the 12mg dose in TRIUMPH-4, and 12.5% at 12mg in the larger TRIUMPH-1 trial

Warns that lead contamination may worsen if USP accepts currently proposed allowance

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