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Based on contraindications documented in FDA-approved GLP-1 prescribing information, these medications are generally not appropriate for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

And the price escalation with higher doses can surprise members who budgeted only for the starting price

Inverse association between iodine status and prevalence of metabolic syndrome: a cross-sectional population-based study in a Chinese moderate iodine intake area

PMID: 26209509

And in the third case, the patient decided to continue the semaglutide just long enough to achieve a target amount of weight loss