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The presence of multiple amide and amine functionalities supports protonation under positive ion mode conditions

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Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]

doi: 10.1186/2001-1326-1-10 101 KingP

SARS-coV-2 infectivity and neurological targets in the brain